By James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli
State-of-the-art reports overlaying significant points of antibodies and intervention opposed to infectious diseases
The connection among antibodies and infectious illnesses has spawned complete comparable fields of research. Antibodies for Infectious Diseases offers views from major learn scientists and summarizes the fantastic development during this quarter right into a unmarried definitive resource.
Providing a vast survey of crucial elements of the sector of antibodies for infectious illnesses, this book
- presents common good points relating constitution, functionality, isotype, and the function of supplement in antibody function
- examines the position of antibodies in antimicrobial immunity with particular targets
- details new equipment for expression of monoclonal antibodies, in vegetation or via move of antibody genes for in vivo expression in taken care of subjects
Antibodies for Infectious Diseases is a finished reference for researchers, pharmaceutical builders, and well-being care pros at the prestige of the improvement of antibody-based treatments for treating infectious ailments. it's also valuable as supplemental examining for higher point existence sciences scholars.
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Additional resources for Antibodies for infectious diseases
Antibody and complement can promote the killing of P. falciparum blood forms by THP-1 cells (a myelomonocytic cell line) and neutrophils (131, 132). In addition, antibodydependent complement-mediated lysis of schizonts results in growth inhibition of P. falciparum (133). Antibodies to P.
A variant human IgG1-Fc mediates improved ADCC. Protein Eng Des Sel 24:671–678. Niwa R, Hatanaka S, Shoji-Hosaka E, Sakurada M, Kobayashi Y, Uehara A, Yokoi H, Nakamura K, Shitara K. 2004. Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 is independent of Fc-q gammaRIIIa functional polymorphism. Clin Cancer Res 10:6248–6255. Hezareh M, Hessell AJ, Jensen RC, van de Winkel JGJ, Parren PWHI. 2001. Effector function activities of a panel of mutants of a 24. 25. 26. 27.
2008. Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases. Nat Med 14:1357–1362. 38. Bruno BJ, Jacobson JM. 2010. Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection. J Antimicrob Chemother 65:1839– 1841. 21 39. Li L, Sun T, Yang K. 2010. Monoclonal CCR5 antibody for treatment of people with HIV infection (review). Cochrane Database Syst Rev 8:CD008439. 40. Quiambao B, Bakker A, Bermal NN. 2009. Evaluation of the safety and neutralizing activity of CL184, a monoclonal antibody cocktail against rabies, in a phase II study in healthy adolescents and children.
Antibodies for infectious diseases by James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli