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Written by means of best specialists within the box, Immunogenetics of Autoimmune affliction summarizes the most recent wisdom within the box of immunogenetics overlaying quite a few themes when it comes to autoimmune ailments. The ebook summarizes the most recent wisdom in a pleasant presentation in keeping with a disorder by way of affliction strategy.
The power to recollect an antigenic come upon for numerous many years, even for a lifestyles time, is likely one of the primary homes of the immune process. This phenomenon referred to as ''immunological memory,'' is the basis upon which the idea that if vaccination rests. for that reason, knowing the mechanisms in which immunological reminiscence is regulated is of paramount significance.
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Extra resources for Annual Review of Immunology Volume 17 1999
The IL-15 linked to the short signal peptide and some of that associated with the longer signal peptide is not secreted but is stored intracellularly, appearing in the nucleus and cytoplasmic components. Production of an intracellular lymphokine is not typical of other soluble interleukin systems. The possibility that IL-15 has biological functions as an intracellular molecule should be explored. IL-15 and IL-2 share some biological activities including the induction of T-cell proliferation, the activation of cytotoxic effector cells, the costimulation of immunoglobulin synthesis by B cells, and the activation of monocytes.
1995. Functional characterization of human interleukin 15 receptor α chain and close linkage of IL15RA and IL-2RA genes. J. Biol. Chem. 270:29862–69 Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN. 1994. Involvement of the Jak-3 Janus kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153– 57 Johnston JA, Bacon CM, Finbloom DS, Rees RC, Kaplan D, Shibuya K, Ortaldo JR, Gupta S, Chen YQ, Giri JD, O’Shea JJ. 1995. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukin 2 and 15.
Immunol. 17:19-49. org by HINARI on 08/31/07. For personal use only. 28. 29. 30. 31. 32. 33. 34. 35. 36. 9:56 QC: NBL/tkj T1: NBL Annual Reviews AR078-02 WALDMANN & TAGAYA Anderson D, Eisenmann J, Grabstein K, Caligiuri MA. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395–403 Suzuki H, Duncan GS, Takimoto H, Mak TW. 1997. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain.
Annual Review of Immunology Volume 17 1999 by Annual Reviews